CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation.
Identifieur interne : 002C90 ( Main/Exploration ); précédent : 002C89; suivant : 002C91CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation.
Auteurs : Michael Jeltsch [Finlande] ; Sawan Kumar Jha ; Denis Tvorogov ; Andrey Anisimov ; Veli-Matti Lepp Nen ; Tanja Holopainen ; Riikka Kivel ; Sagrario Ortega ; Terhi K Rpanen ; Kari Alitalo [Finlande]Source :
- Circulation [ 1524-4539 ] ; 2014.
Descripteurs français
- KwdFr :
- Adenoviridae (génétique), Animaux, Cellules HEK293, Cellules cultivées, Endothélium vasculaire (cytologie), Endothélium vasculaire (métabolisme), Facteur de croissance endothéliale vasculaire de type C (métabolisme), Humains, Lignées consanguines de souris, Lymphangiogenèse (physiologie), Modèles animaux, Muscles squelettiques (), Muscles squelettiques (métabolisme), Mâle, Néovascularisation physiologique (physiologie), Procollagen peptidase (métabolisme), Protéines ADAM (métabolisme), Protéines ADAMTS, Protéines de liaison au calcium (génétique), Protéines de liaison au calcium (métabolisme), Protéines suppresseurs de tumeurs (génétique), Protéines suppresseurs de tumeurs (métabolisme), Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme), Souris, Techniques in vitro, Transfection.
- MESH :
- cytologie : Endothélium vasculaire.
- génétique : Adenoviridae, Protéines de liaison au calcium, Protéines suppresseurs de tumeurs.
- métabolisme : Endothélium vasculaire, Facteur de croissance endothéliale vasculaire de type C, Muscles squelettiques, Procollagen peptidase, Protéines ADAM, Protéines de liaison au calcium, Protéines suppresseurs de tumeurs, Récepteur-3 au facteur croissance endothéliale vasculaire.
- physiologie : Lymphangiogenèse, Néovascularisation physiologique.
- Animaux, Cellules HEK293, Cellules cultivées, Humains, Lignées consanguines de souris, Modèles animaux, Muscles squelettiques, Mâle, Protéines ADAMTS, Souris, Techniques in vitro, Transfection.
English descriptors
- KwdEn :
- ADAM Proteins (metabolism), ADAMTS Proteins, Adenoviridae (genetics), Animals, Calcium-Binding Proteins (genetics), Calcium-Binding Proteins (metabolism), Cells, Cultured, Endothelium, Vascular (cytology), Endothelium, Vascular (metabolism), HEK293 Cells, Humans, In Vitro Techniques, Lymphangiogenesis (physiology), Male, Mice, Mice, Inbred Strains, Models, Animal, Muscle, Skeletal (blood supply), Muscle, Skeletal (metabolism), Neovascularization, Physiologic (physiology), Procollagen N-Endopeptidase (metabolism), Transfection, Tumor Suppressor Proteins (genetics), Tumor Suppressor Proteins (metabolism), Vascular Endothelial Growth Factor C (metabolism), Vascular Endothelial Growth Factor Receptor-3 (metabolism).
- MESH :
- chemical , genetics : Calcium-Binding Proteins, Tumor Suppressor Proteins.
- chemical , metabolism : ADAM Proteins, Calcium-Binding Proteins, Procollagen N-Endopeptidase, Tumor Suppressor Proteins, Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor Receptor-3.
- chemical : ADAMTS Proteins.
- blood supply : Muscle, Skeletal.
- cytology : Endothelium, Vascular.
- genetics : Adenoviridae.
- metabolism : Endothelium, Vascular, Muscle, Skeletal.
- physiology : Lymphangiogenesis, Neovascularization, Physiologic.
- Animals, Cells, Cultured, HEK293 Cells, Humans, In Vitro Techniques, Male, Mice, Mice, Inbred Strains, Models, Animal, Transfection.
Abstract
Hennekam lymphangiectasia-lymphedema syndrome (Online Mendelian Inheritance in Man 235510) is a rare autosomal recessive disease, which is associated with mutations in the CCBE1 gene. Because of the striking phenotypic similarity of embryos lacking either the Ccbe1 gene or the lymphangiogenic growth factor Vegfc gene, we searched for collagen- and calcium-binding epidermal growth factor domains 1 (CCBE1) interactions with the vascular endothelial growth factor-C (VEGF-C) growth factor signaling pathway, which is critical in embryonic and adult lymphangiogenesis.
DOI: 10.1161/CIRCULATIONAHA.113.002779
PubMed: 24552833
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001669
- to stream PubMed, to step Curation: 001669
- to stream PubMed, to step Checkpoint: 001669
- to stream Ncbi, to step Merge: 006333
- to stream Ncbi, to step Curation: 006333
- to stream Ncbi, to step Checkpoint: 006333
- to stream Main, to step Merge: 002C95
- to stream Main, to step Curation: 002C90
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation.</title><author><name sortKey="Jeltsch, Michael" sort="Jeltsch, Michael" uniqKey="Jeltsch M" first="Michael" last="Jeltsch">Michael Jeltsch</name><affiliation wicri:level="4"><nlm:affiliation>Wihuri Research Institute (M.J., A.A., V.-M.L., R.K., K.A.), Translational Cancer Biology Program (M.J., S.K.J., D.T., A.A., T.H., K.A.), and Department of Biomedicine (M.J.), Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; Biotechnology Programme, Spanish National Cancer Research Centre, Madrid, Spain (S.O.); Hubrecht Institute, Utrecht, The Netherlands (T.K.); and Helsinki University Central Hospital, Helsinki, Finland (K.A.).</nlm:affiliation><orgName type="university">Université d'Helsinki</orgName><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Jha, Sawan Kumar" sort="Jha, Sawan Kumar" uniqKey="Jha S" first="Sawan Kumar" last="Jha">Sawan Kumar Jha</name></author><author><name sortKey="Tvorogov, Denis" sort="Tvorogov, Denis" uniqKey="Tvorogov D" first="Denis" last="Tvorogov">Denis Tvorogov</name></author><author><name sortKey="Anisimov, Andrey" sort="Anisimov, Andrey" uniqKey="Anisimov A" first="Andrey" last="Anisimov">Andrey Anisimov</name></author><author><name sortKey="Lepp Nen, Veli Matti" sort="Lepp Nen, Veli Matti" uniqKey="Lepp Nen V" first="Veli-Matti" last="Lepp Nen">Veli-Matti Lepp Nen</name></author><author><name sortKey="Holopainen, Tanja" sort="Holopainen, Tanja" uniqKey="Holopainen T" first="Tanja" last="Holopainen">Tanja Holopainen</name></author><author><name sortKey="Kivel, Riikka" sort="Kivel, Riikka" uniqKey="Kivel R" first="Riikka" last="Kivel">Riikka Kivel</name></author><author><name sortKey="Ortega, Sagrario" sort="Ortega, Sagrario" uniqKey="Ortega S" first="Sagrario" last="Ortega">Sagrario Ortega</name></author><author><name sortKey="K Rpanen, Terhi" sort="K Rpanen, Terhi" uniqKey="K Rpanen T" first="Terhi" last="K Rpanen">Terhi K Rpanen</name></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><affiliation><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24552833</idno><idno type="pmid">24552833</idno><idno type="doi">10.1161/CIRCULATIONAHA.113.002779</idno><idno type="wicri:Area/PubMed/Corpus">001669</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001669</idno><idno type="wicri:Area/PubMed/Curation">001669</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001669</idno><idno type="wicri:Area/PubMed/Checkpoint">001669</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001669</idno><idno type="wicri:Area/Ncbi/Merge">006333</idno><idno type="wicri:Area/Ncbi/Curation">006333</idno><idno type="wicri:Area/Ncbi/Checkpoint">006333</idno><idno type="wicri:Area/Main/Merge">002C95</idno><idno type="wicri:Area/Main/Curation">002C90</idno><idno type="wicri:Area/Main/Exploration">002C90</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation.</title><author><name sortKey="Jeltsch, Michael" sort="Jeltsch, Michael" uniqKey="Jeltsch M" first="Michael" last="Jeltsch">Michael Jeltsch</name><affiliation wicri:level="4"><nlm:affiliation>Wihuri Research Institute (M.J., A.A., V.-M.L., R.K., K.A.), Translational Cancer Biology Program (M.J., S.K.J., D.T., A.A., T.H., K.A.), and Department of Biomedicine (M.J.), Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; Biotechnology Programme, Spanish National Cancer Research Centre, Madrid, Spain (S.O.); Hubrecht Institute, Utrecht, The Netherlands (T.K.); and Helsinki University Central Hospital, Helsinki, Finland (K.A.).</nlm:affiliation><orgName type="university">Université d'Helsinki</orgName><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Jha, Sawan Kumar" sort="Jha, Sawan Kumar" uniqKey="Jha S" first="Sawan Kumar" last="Jha">Sawan Kumar Jha</name></author><author><name sortKey="Tvorogov, Denis" sort="Tvorogov, Denis" uniqKey="Tvorogov D" first="Denis" last="Tvorogov">Denis Tvorogov</name></author><author><name sortKey="Anisimov, Andrey" sort="Anisimov, Andrey" uniqKey="Anisimov A" first="Andrey" last="Anisimov">Andrey Anisimov</name></author><author><name sortKey="Lepp Nen, Veli Matti" sort="Lepp Nen, Veli Matti" uniqKey="Lepp Nen V" first="Veli-Matti" last="Lepp Nen">Veli-Matti Lepp Nen</name></author><author><name sortKey="Holopainen, Tanja" sort="Holopainen, Tanja" uniqKey="Holopainen T" first="Tanja" last="Holopainen">Tanja Holopainen</name></author><author><name sortKey="Kivel, Riikka" sort="Kivel, Riikka" uniqKey="Kivel R" first="Riikka" last="Kivel">Riikka Kivel</name></author><author><name sortKey="Ortega, Sagrario" sort="Ortega, Sagrario" uniqKey="Ortega S" first="Sagrario" last="Ortega">Sagrario Ortega</name></author><author><name sortKey="K Rpanen, Terhi" sort="K Rpanen, Terhi" uniqKey="K Rpanen T" first="Terhi" last="K Rpanen">Terhi K Rpanen</name></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><affiliation><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author></analytic><series><title level="j">Circulation</title><idno type="eISSN">1524-4539</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ADAM Proteins (metabolism)</term><term>ADAMTS Proteins</term><term>Adenoviridae (genetics)</term><term>Animals</term><term>Calcium-Binding Proteins (genetics)</term><term>Calcium-Binding Proteins (metabolism)</term><term>Cells, Cultured</term><term>Endothelium, Vascular (cytology)</term><term>Endothelium, Vascular (metabolism)</term><term>HEK293 Cells</term><term>Humans</term><term>In Vitro Techniques</term><term>Lymphangiogenesis (physiology)</term><term>Male</term><term>Mice</term><term>Mice, Inbred Strains</term><term>Models, Animal</term><term>Muscle, Skeletal (blood supply)</term><term>Muscle, Skeletal (metabolism)</term><term>Neovascularization, Physiologic (physiology)</term><term>Procollagen N-Endopeptidase (metabolism)</term><term>Transfection</term><term>Tumor Suppressor Proteins (genetics)</term><term>Tumor Suppressor Proteins (metabolism)</term><term>Vascular Endothelial Growth Factor C (metabolism)</term><term>Vascular Endothelial Growth Factor Receptor-3 (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adenoviridae (génétique)</term><term>Animaux</term><term>Cellules HEK293</term><term>Cellules cultivées</term><term>Endothélium vasculaire (cytologie)</term><term>Endothélium vasculaire (métabolisme)</term><term>Facteur de croissance endothéliale vasculaire de type C (métabolisme)</term><term>Humains</term><term>Lignées consanguines de souris</term><term>Lymphangiogenèse (physiologie)</term><term>Modèles animaux</term><term>Muscles squelettiques ()</term><term>Muscles squelettiques (métabolisme)</term><term>Mâle</term><term>Néovascularisation physiologique (physiologie)</term><term>Procollagen peptidase (métabolisme)</term><term>Protéines ADAM (métabolisme)</term><term>Protéines ADAMTS</term><term>Protéines de liaison au calcium (génétique)</term><term>Protéines de liaison au calcium (métabolisme)</term><term>Protéines suppresseurs de tumeurs (génétique)</term><term>Protéines suppresseurs de tumeurs (métabolisme)</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme)</term><term>Souris</term><term>Techniques in vitro</term><term>Transfection</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Calcium-Binding Proteins</term><term>Tumor Suppressor Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>ADAM Proteins</term><term>Calcium-Binding Proteins</term><term>Procollagen N-Endopeptidase</term><term>Tumor Suppressor Proteins</term><term>Vascular Endothelial Growth Factor C</term><term>Vascular Endothelial Growth Factor Receptor-3</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>ADAMTS Proteins</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Endothélium vasculaire</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Endothelium, Vascular</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenoviridae</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adenoviridae</term><term>Protéines de liaison au calcium</term><term>Protéines suppresseurs de tumeurs</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endothelium, Vascular</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Endothélium vasculaire</term><term>Facteur de croissance endothéliale vasculaire de type C</term><term>Muscles squelettiques</term><term>Procollagen peptidase</term><term>Protéines ADAM</term><term>Protéines de liaison au calcium</term><term>Protéines suppresseurs de tumeurs</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphangiogenèse</term><term>Néovascularisation physiologique</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymphangiogenesis</term><term>Neovascularization, Physiologic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>HEK293 Cells</term><term>Humans</term><term>In Vitro Techniques</term><term>Male</term><term>Mice</term><term>Mice, Inbred Strains</term><term>Models, Animal</term><term>Transfection</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules HEK293</term><term>Cellules cultivées</term><term>Humains</term><term>Lignées consanguines de souris</term><term>Modèles animaux</term><term>Muscles squelettiques</term><term>Mâle</term><term>Protéines ADAMTS</term><term>Souris</term><term>Techniques in vitro</term><term>Transfection</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hennekam lymphangiectasia-lymphedema syndrome (Online Mendelian Inheritance in Man 235510) is a rare autosomal recessive disease, which is associated with mutations in the CCBE1 gene. Because of the striking phenotypic similarity of embryos lacking either the Ccbe1 gene or the lymphangiogenic growth factor Vegfc gene, we searched for collagen- and calcium-binding epidermal growth factor domains 1 (CCBE1) interactions with the vascular endothelial growth factor-C (VEGF-C) growth factor signaling pathway, which is critical in embryonic and adult lymphangiogenesis.</div></front></TEI><affiliations><list><country><li>Finlande</li></country><region><li>Uusimaa</li></region><settlement><li>Helsinki</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><noCountry><name sortKey="Anisimov, Andrey" sort="Anisimov, Andrey" uniqKey="Anisimov A" first="Andrey" last="Anisimov">Andrey Anisimov</name><name sortKey="Holopainen, Tanja" sort="Holopainen, Tanja" uniqKey="Holopainen T" first="Tanja" last="Holopainen">Tanja Holopainen</name><name sortKey="Jha, Sawan Kumar" sort="Jha, Sawan Kumar" uniqKey="Jha S" first="Sawan Kumar" last="Jha">Sawan Kumar Jha</name><name sortKey="K Rpanen, Terhi" sort="K Rpanen, Terhi" uniqKey="K Rpanen T" first="Terhi" last="K Rpanen">Terhi K Rpanen</name><name sortKey="Kivel, Riikka" sort="Kivel, Riikka" uniqKey="Kivel R" first="Riikka" last="Kivel">Riikka Kivel</name><name sortKey="Lepp Nen, Veli Matti" sort="Lepp Nen, Veli Matti" uniqKey="Lepp Nen V" first="Veli-Matti" last="Lepp Nen">Veli-Matti Lepp Nen</name><name sortKey="Ortega, Sagrario" sort="Ortega, Sagrario" uniqKey="Ortega S" first="Sagrario" last="Ortega">Sagrario Ortega</name><name sortKey="Tvorogov, Denis" sort="Tvorogov, Denis" uniqKey="Tvorogov D" first="Denis" last="Tvorogov">Denis Tvorogov</name></noCountry><country name="Finlande"><region name="Uusimaa"><name sortKey="Jeltsch, Michael" sort="Jeltsch, Michael" uniqKey="Jeltsch M" first="Michael" last="Jeltsch">Michael Jeltsch</name></region><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002C90 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002C90 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:24552833
|texte= CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24552833" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |